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Neuroprotective effects of the fractions of Ocimum basilicum in seizures induced by pentylenetetrazole in mice
- Source :
- Avicenna Journal of Phytomedicine, Vol 12, Iss 6, Pp 614-626 (2022)
- Publication Year :
- 2022
- Publisher :
- Mashhad University of Medical Sciences, 2022.
-
Abstract
- Objective: Neuroprotective and antioxidant effects of Ocimum basilicum (O. basilicum) against pentylenetetrazole (PTZ)-induced seizures were investigated. Materials and Methods: Mice were divided as follows: (Group 1) Control, (Group 2) PTZ, (Groups 3-5) 50,100 and 200 mg/kg hydro-ethanolic (HE) extract, and (Groups 6-8) 200 mg/kg ethyl-acetate (EAF), N-hexane (NHF) and water (WF) fractions. Minimal clonic seizures (MCS) and generalized tonic-clonic seizures (GTCS) latencies were measured. Biochemical and histological studies were done.Results: MCS and GTCS latency in HE groups were longer than the PTZ group (p
Details
- Language :
- English
- ISSN :
- 22287930 and 22287949
- Volume :
- 12
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Avicenna Journal of Phytomedicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.779f7760006448b79d9d31164d8372ca
- Document Type :
- article
- Full Text :
- https://doi.org/10.22038/ajp.2022.20470