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Preparing a novel baicalin-loaded microemulsion-based gel for transdermal delivery and testing its anti-gout effect
- Source :
- Saudi Pharmaceutical Journal, Vol 32, Iss 6, Pp 102100- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- We previously demonstrated that baicalin had efficacy against gouty arthritis (GA) by oral administration. In this paper, a novel baicalin-loaded microemulsion-based gel (B-MEG) was prepared and assessed for the transdermal delivery of baicalin against GA. The preparation method and transdermal capability of B-MEG was screened and optimized using the central composite design, Franz diffusion cell experiments, and the split-split plot design. Skin irritation tests were performed in guinea pigs. The anti-gout effects were evaluated using mice. The optimized B-MEG comprised of 50 % pH 7.4 phosphate buffered saline, 4.48 % ethyl oleate, 31.64 % tween 80, 13.88 % glycerin, 2 % borneol, 0.5 % clove oil and 0.5 % xanthan gum, with a baicalin content of (10.42 ± 0.08) mg/g and particle size of (15.71 ± 0.41) nm. After 12 h, the cumulative amount of baicalin permeated from B-MEG was (672.14 ± 44.11) μg·cm−2. No significant skin irritation was observed following B-MEG application. Compared to the model group, B-MEG groups significantly decreased the rate of auricular swelling (P
Details
- Language :
- English
- ISSN :
- 13190164
- Volume :
- 32
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Saudi Pharmaceutical Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.778cc5c0f6145e4be712a6e54fbe573
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jsps.2024.102100