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A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization

Authors :
Jue-Sheng Ong
Suzanne C. Dixon-Suen
Xikun Han
Jiyuan An
Esophageal Cancer Consortium
and Me Research Team
Upekha Liyanage
Jean-Cluade Dusingize
Johannes Schumacher
Ines Gockel
Anne Böhmer
Janusz Jankowski
Claire Palles
Tracy O’Mara
Amanda Spurdle
Matthew H. Law
Mark M. Iles
Paul Pharoah
Andrew Berchuck
Wei Zheng
Aaron P. Thrift
Catherine Olsen
Rachel E. Neale
Puya Gharahkhani
Penelope M. Webb
Stuart MacGregor
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Studies of the genetic association between vitamin D and cancer risk have typically been underpowered. Here the authors analyse this using Mendelian Randomisation with more than 70 vitamin D variants obtained from the UK Biobank and large-scale data from various consortia, confirming null associations between vitamin D and most cancers.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7744806243e1477e9baddee9305b938e
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-20368-w