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RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Lysosomes move along microtubule tracks, and Arl8b is known to stimulate their anterograde transport. Here, the authors identified RUFY3 as an Arl8b effector that interacts with dynein-dynactin to drive retrograde transport and perinuclear lysosome positioning.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.772bc6dcc1674b559be37e83a90e9554
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-29077-y