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Effect of mushrooms on obesity in animal models: study protocol for a systematic review and meta-analysis

Authors :
Denise Grotto
Isabella Ferreira Camargo
Katia Kodaira
Lauren Giustti Mazzei
Juliana Castro
Raquel Andrade Leite Vieira
Cristiane de Cásia Bergamaschi
Luciane Cruz Lopes
Source :
Systematic Reviews, Vol 8, Iss 1, Pp 1-5 (2019)
Publication Year :
2019
Publisher :
BMC, 2019.

Abstract

Abstract Background Obesity and its consequences are worldwide epidemic problem; therefore, studies with strategies and mechanisms that favor weight loss to improve outcomes in health are necessary. Effects of mushrooms on body weight are uncertain. The aim of this systematic review is to determine the efficacy of mushrooms in weight loss in animal preclinical models. Method This is a systematic review of preclinical studies of animal models of obesity (any type of non-aquatic mammal), which were exposed to edible and medicinal mushrooms orally in comparison with the control. The following databases will be used: MEDLINE (PubMed), Web of Science, BIOSIS, SCOPUS, and gray literature. There will be no restriction of language, date, or publication status. The primary outcome will be body weight loss. And the secondary outcomes include the total amount of food consumed by the animals, analysis of metabolic parameters, inflammatory mediators, mortality for any causes, and any adverse effect reported. A team of reviewers will select, in pairs and independently, the titles and abstracts, extract data from qualifying studies, and assess bias risk (using SYstematic Review Centre for Laboratory animal Experimentation SYRCLE’s risk of bias tool and the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) checklist). The standardized mean difference (SMD) will be calculated to measure treatment effect, with 95% confidence intervals (95% CI). The heterogeneity between-study will be calculated by I 2 inconsistency values and Cochran’s Q statistical test, where I 2 > 50% and/or p < 0.10 suggest high heterogeneity meta-analyses of random effects will be conducted as possible. Discussion Although many experimental studies about the effects of mushrooms on obesity have already been published, there is still no consensus in the literature. This study will provide evidences of preclinical research on mushrooms and their relation to body weight loss in animal models of obesity, being non-aquatic mammals. Also, this systematic review will show the limitations and strengths of the studies available in the literature, as well as it will to encourage the financing of new studies by public health managers and governmental entities. Systematic review registration PROSPERO (CRD42019125299).

Details

Language :
English
ISSN :
20464053
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Systematic Reviews
Publication Type :
Academic Journal
Accession number :
edsdoj.770fdd93a7194eab8df251cd40aa6498
Document Type :
article
Full Text :
https://doi.org/10.1186/s13643-019-1205-3