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DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain
- Source :
- Clinical Epigenetics, Vol 16, Iss 1, Pp 1-15 (2024)
- Publication Year :
- 2024
- Publisher :
- BMC, 2024.
-
Abstract
- Abstract Background Plasma growth differentiation factor 15 (GDF15) and N‐terminal proB‐type natriuretic peptide (NT‐proBNP) are cardiovascular biomarkers that associate with a range of diseases. Epigenetic scores (EpiScores) for GDF15 and NT-proBNP may provide new routes for risk stratification. Results In the Generation Scotland cohort (N ≥ 16,963), GDF15 levels were associated with incident dementia, ischaemic stroke and type 2 diabetes, whereas NT-proBNP levels were associated with incident ischaemic heart disease, ischaemic stroke and type 2 diabetes (all PFDR 95%) with levels of GDF15 and NT-proBNP, respectively. EpiScores for GDF15 and NT-proBNP were trained in a subset of the population. The GDF15 EpiScore replicated protein associations with incident dementia, type 2 diabetes and ischaemic stroke in the Generation Scotland test set (hazard ratios (HR) range 1.36–1.41, PFDR
- Subjects :
- GDF15
NT-proBNP
Epigenetic
DNA methylation
Dementia
Diabetes
Medicine
Genetics
QH426-470
Subjects
Details
- Language :
- English
- ISSN :
- 18687083
- Volume :
- 16
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical Epigenetics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.76e8233ab631452ab514eb985f52d351
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s13148-024-01734-7