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Pathophysiological Characteristics of Diabetic Ocular Complications in Spontaneously Diabetic Torii Rat
- Source :
- Journal of Ophthalmology, Vol 2010 (2010)
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- The Spontaneously Diabetic Torii (SDT) rat, a nonobese type 2 diabetes model, develops severe diabetic retinopathy as result of chronic severe hyperglycemia. Although existing diabetes animal models also develop ocular complications, severe retinal lesions frequently observed in human diabetes patients such as preretinal neovascularization or retinal detachment are not found. Distinctive features in SDT rat are hypermature cataract, tractional retinal detachment with fibrous proliferation, and massive hemorrhaging in the anterior chamber. These pathophysiological changes are caused by sustained hyperglycemic condition and subsequent increased expression of vascular endothelial growth factor (VEGF) in retina, iris, and ciliary body. Although some differences in diabetic retinopathy exist between SDT rats and humans (e.g., a low incidence of neovascular formation and poor development of nonperfused area are found in this animal), SDT rat will be a useful model in studies of the pathogenesis and treatment of diabetic retinopathy.
- Subjects :
- Ophthalmology
RE1-994
Subjects
Details
- Language :
- English
- ISSN :
- 2090004X and 20900058
- Volume :
- 2010
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.76b24ba5df6a4615ae6cc9e815b66bc8
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2010/615641