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Prediction of Grade Reclassification of Prostate Cancer Patients on Active Surveillance through the Combination of a Three-miRNA Signature and Selected Clinical Variables

Authors :
Paolo Gandellini
Chiara Maura Ciniselli
Tiziana Rancati
Cristina Marenghi
Valentina Doldi
Rihan El Bezawy
Mara Lecchi
Melanie Claps
Mario Catanzaro
Barbara Avuzzi
Elisa Campi
Maurizio Colecchia
Fabio Badenchini
Paolo Verderio
Riccardo Valdagni
Nadia Zaffaroni
Source :
Cancers, Vol 13, Iss 10, p 2433 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Active surveillance (AS) has evolved as a strategy alternative to radical treatments for very low risk and low-risk prostate cancer (PCa). However, current criteria for selecting AS patients are still suboptimal. Here, we performed an unprecedented analysis of the circulating miRNome to investigate whether specific miRNAs associated with disease reclassification can provide risk refinement to standard clinicopathological features for improving patient selection. The global miRNA expression profiles were assessed in plasma samples prospectively collected at baseline from 386 patients on AS included in three independent mono-institutional cohorts (training, testing and validation sets). A three-miRNA signature (miR-511-5p, miR-598-3p and miR-199a-5p) was found to predict reclassification in all patient cohorts (training set: AUC 0.74, 95% CI 0.60–0.87, testing set: AUC 0.65, 95% CI 0.51–0.80, validation set: AUC 0.68, 95% CI 0.56–0.80). Importantly, the addition of the three-miRNA signature improved the performance of the clinical model including clinicopathological variables only (AUC 0.70, 95% CI 0.61–0.78 vs. 0.76, 95% CI 0.68–0.84). Overall, we trained, tested and validated a three-miRNA signature which, combined with selected clinicopathological variables, may represent a promising biomarker to improve on currently available clinicopathological risk stratification tools for a better selection of truly indolent PCa patients suitable for AS.

Details

Language :
English
ISSN :
20726694
Volume :
13
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
edsdoj.76091f67aa584951bf421b2344ae6a4b
Document Type :
article
Full Text :
https://doi.org/10.3390/cancers13102433