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Comparison of Approaches to Revascularization in Patients With Multivessel Coronary Artery Disease Presenting With ST‐Segment Elevation Myocardial Infarction: Meta‐analyses of Randomized Control Trials
- Source :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 4, Iss 12, Pp n/a-n/a (2015)
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Background Significant controversy exists regarding the best approach for nonculprit vessel revascularization in patients with multivessel coronary artery disease presenting with ST‐segment elevation myocardial infarction. We conducted a systematic investigation to pool data from current randomized controlled trials (RCTs) to assess optimal treatment strategies in this patient population. Methods and Results A comprehensive search of SCOPUS from inception through May 2015 was performed using predefined criteria. We compared efficacy and safety outcomes of different approaches by categorizing the studies into 3 groups: (1) complete revascularization (CR) versus culprit lesion revascularization (CL) at index hospitalization, (2) CR at index hospitalization versus staged revascularization (SR) of nonculprit vessels at a separate hospitalization, and (3) comparison of SR versus CL. Eight eligible RCTs met the inclusion criteria: (1) CR versus CL (6 RCTs, n=1727) (2) CR versus SR (3 RCTs, n=311), and (3) SR versus CL (1 RCT, n=149). We observed significantly lower rates of major adverse cardiovascular events, revascularization, and repeat percutaneous coronary interventions among patients treated with CR and SR compared with a CL approach (P
Details
- Language :
- English
- ISSN :
- 20479980
- Volume :
- 4
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7600e98fa06b4a12b8debf3e973bdb91
- Document Type :
- article
- Full Text :
- https://doi.org/10.1161/JAHA.115.002540