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Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism

Authors :
Ming-Liang Lee
Hirokazu Matsunaga
Yuki Sugiura
Takahiro Hayasaka
Izumi Yamamoto
Taiga Ishimoto
Daigo Imoto
Makoto Suematsu
Norifumi Iijima
Kazuhiro Kimura
Sabrina Diano
Chitoku Toda
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

The ventromedial hypothalamus regulates systemic glucose metabolism. Here the authors show that cytosolic phospholipase A2 mediated phospholipid metabolism contributes to this regulation in healthy animals but exert deteriorating effects on glucose homeostasis under high-fat-diet feeding.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.75bb48442764a558ebec50556d76a3e
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-22431-6