Back to Search Start Over

The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner

Authors :
Subramanya Srikantan
Yilun Deng
Zi-Ming Cheng
Anqi Luo
Yuejuan Qin
Qing Gao
Glaiza-Mae Sande-Docor
Sifan Tao
Xingyu Zhang
Nathan Harper
Chris E. Shannon
Marcel Fourcaudot
Zhi Li
Balakuntalam S. Kasinath
Stephen Harrison
Sunil Ahuja
Robert L. Reddick
Lily Q. Dong
Muhammad Abdul-Ghani
Luke Norton
Ricardo C. T. Aguiar
Patricia L. M. Dahia
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

TMEM127 is a tumor suppressor protein, loss of which predisposes to catecholamine-secreting tumors. Here the authors show that TMEM127 expression is modulated by nutritional status and that it has a role in regulating organismal insulin sensitivity.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.759408e47c5a4d35885debb0d56f6eb3
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-12661-0