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Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis

Authors :
Philippe Georgel
Karine Crozat
Source :
Viruses, Vol 1, Iss 3, Pp 460-483 (2009)
Publication Year :
2009
Publisher :
MDPI AG, 2009.

Abstract

Host resistance to infection depends on the efficiency with which innate immune responses keep the infectious agent in check. Innate immunity encompasses components with sensing, signaling and effector properties. These elements with nonredundant functions are encoded by a set of host genes, the resistome. Here, we review our findings concerning the resistome. We have screened randomly mutagenized mice for susceptibility to a natural opportunistic pathogen, the mouse cytomegalovirus. We found that some genes with initially no obvious functions in innate immunity may be critical for host survival to infections, falling into a newly defined category of genes of the resistome.

Details

Language :
English
ISSN :
19994915
Volume :
1
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
edsdoj.757405f79e4c45c9ada33293f016e3ac
Document Type :
article
Full Text :
https://doi.org/10.3390/v1030460