Back to Search
Start Over
Late occurrence of granular dystrophy in bilateral keratoconus: Penetrating keratoplasty and long-term follow-up
- Source :
- Indian Journal of Ophthalmology, Vol 59, Iss 5, Pp 398-400 (2011)
- Publication Year :
- 2011
- Publisher :
- Wolters Kluwer Medknow Publications, 2011.
-
Abstract
- We report a rare case of keratoconus with granular dystrophy with a follow-up of two decades, documenting the sequential presentation of two diseases confirmed by histology and genetic studies. A 13-year-old boy was diagnosed in 1988 with keratoconus in both eyes (BE) based on slit-lamp biomicroscopy findings of corneal ectasia in BE accompanied by Fleischer′s ring, Vogt′s striae, a small, old, healed hydrops. The left eye (LE) had central corneal thinning and scar in the central area involving the mid and posterior stroma secondary to healed hydrops. Penetrating keratoplasty (PKP) was advised. The boy was lost to follow-up till 1991 and presented with white, dot-like opacities in the central cornea in the RE only, suggestive of granular corneal dystrophy. Similar findings of white, dot-like opacities were noted in the LE in 1995 and the patient subsequently underwent PKP in BE. Histopathology of corneal buttons confirmed the presence of patchy, crystal-like orange deposits, which stained bright red with Masson′s trichrome. Mutational analysis of the TGFBI gene in patient′s DNA revealed a heterozygous mutation corresponding to a change in Arg555Trp in the keratoepithelin protein. Granular dystrophy recurred after 8 years in the RE.
- Subjects :
- Pediatric traumatic cataract
primary posterior capsulotomy
posterior capsule opacification
square-edge intraocular lens
visual axis opacification
Multifocal electroretinogram
principal components′
analysis
retinitis pigmentosa
Behcet′s disease
HLA-B51
optical coherence tomography
macular hole
Graves′ ophthalmopathy
thyroid eye disease
unilateral
Assam
corneal ulcer
fusarium
mycotic keratitis
Antifungal sensitivity testing
amphotericin B
Aspergillus
fungal keratitis
polymerase chain reaction--single-stranded conformational polymorphism.
Lid coloboma
limbal dermoid
nasopalpebral lipoma-coloboma syndrome
Bilateral
breast metastasis
extraocular muscle
Conventional dacryocystorhinostomy
trans-canalicular laser-assisted dacryocystorhinostomy
Eye surgery
operation theater
parental presence
squint surgery
witnessing a surgery
Centrocecal visual field defect
cilioretinal artery occlusion
fluorescein angiogram
intranasal cocaine
Caesarean section
epidural anesthesia
Horner′s syndrome
Acute myeloid leukemia
hypopyon
masquerade syndrome
Low-fluence photodynamic therapy
choroidal neovascular membrane
choroidal osteoma
ranibizumab
Cataract surgery
perfluorocarbon liquid
postoperative inflammation
Bilateral keratoconus
granular dystrophy
late occurrence
Ophthalmology
RE1-994
Subjects
Details
- Language :
- English
- ISSN :
- 03014738 and 19983689
- Volume :
- 59
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Indian Journal of Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.74b2e46fddd84402be3551cab5a82160
- Document Type :
- article
- Full Text :
- https://doi.org/10.4103/0301-4738.83624