Hyperhomocysteinemia prevalence among patients with venous thromboembolism

Aims The objectives of this study were to determine the plasma homocysteine (Hcy) levels and the prevalence of Hyperhomocysteinemia (HHC) in a group of Tunisian patients with deep vein thrombosis (DVT) by comparing it with healthy controls.Methods it was an observational case-control study including patients hospitalized for the management of unprovoked DVT. For each subject, a routine biochemical assay was conducted, including plasma homocysteine measurement and determination of vitamin B12 and B9 levels, as these vitamins are essential for assessing hyperhomocysteinemia in DVT patients due to their role in regulating homocysteine.Results We observed an increased mean plasma Hcy level compared to controls and the prevalence of Hyperhomocysteinemia 61.7% against 4% in the control subjects. The risk of developing DVT with HHC is 3.54.Conclusion Our study found that homocysteine levels were higher in patients with DVT than in controls.