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Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer
- Source :
- Investigative and Clinical Urology, Vol 62, Iss 6, Pp 641-649 (2021)
- Publication Year :
- 2021
- Publisher :
- Korean Urological Association, 2021.
-
Abstract
- Purpose: Many studies identified that the preoperative neutrophil-to-lymphocyte ratio (PNLR) was associated with patient prognosis in non-muscle-invasive bladder cancer (NMIBC). We hypothesized that PNLR could be prognostic in patients with histological variants of NMIBC (VH-NMIBC). Materials and Methods: This retrospective study included patients with VH-NMIBC admitted at our center between January 2009 and May 2019. The best cut-off value of NLR was measured by the receiver operating characteristic curve and Youden index. The Kaplan-Meier method and Cox proportional hazard regression models were employed to evaluate the association between PNLR and disease prognosis, including recurrence-free survival (RFS), progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS). Results: A total of 243 patients with VH-NMIBC were enrolled in our study. According to the Kaplan-Meier method results, patients with PNLR ≥2.2 were associated with poor RFS (p
Details
- Language :
- English
- ISSN :
- 24660493 and 2466054X
- Volume :
- 62
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Investigative and Clinical Urology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7483ada899804b7c8b0a5f295531d87a
- Document Type :
- article
- Full Text :
- https://doi.org/10.4111/icu.20210278