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Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Bicuspid aortic valve (BAV) is the most common human congenital cardiovascular malformation. Here, the authors perform a genome-wide association study for BAV and identify risk variants in the gene region of cardiac-specific transcription factor GATA4 and implicate GATA4 in heart valve development.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.746483d8d43040b4bb874c6651724a72
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms15481