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Time-varying SUVr reflects the dynamics of dopamine increases during methylphenidate challenges in humans

Authors :
Dardo Tomasi
Peter Manza
Jean Logan
Ehsan Shokri-Kojori
Michele-Vera Yonga
Danielle Kroll
Dana Feldman
Katherine McPherson
Catherine Biesecker
Evan Dennis
Allison Johnson
Kai Yuan
Wen-Tung Wang
John A. Butman
Gene-Jack Wang
Nora D. Volkow
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Combined PET imaging and mathematical simulations reveal that the rate of dopamine increase in the striatum underlies self-reports of drug “high” in response to oral and intravenous methylphenidate challenges in humans

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.7438493119da4cdb8fb6d112347e0e5c
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04545-3