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Penetration Sites and Migratory Routes of Angiostrongylus costaricensis in the Experimental Intermediate Host (Sarasinula marginata)
- Source :
- Memorias do Instituto Oswaldo Cruz, Vol 94, Iss 4, Pp 549-556 (1999)
- Publication Year :
- 1999
- Publisher :
- Fundação Oswaldo Cruz (FIOCRUZ), 1999.
-
Abstract
- The intermediate hosts of Angiostrongylus costaricensis are terrestrian molluscs, mostly of the family Veronicellidae. The present work aimed at clarifying more accurately the sites of penetration and the migratory routes of A. costaricensis in the tissue slugs and at verifying the pattern of the perilarval reaction at different times of infection. Slugs were individually infected with 5,000 L1, and killed from 30 min to 30 days after infection. From 30 min up to 2 hr after infection, L1 were found within the lumen of different segments of the digestive tube having their number diminished in more advanced times after exposition until complete disappearance. After 30 min of exposition, percutaneous infection occurred, simultaneously to oral infection. Perilarval reaction was observed from 2 hr of infection around larvae in fibromuscular layer, appearing later (after 6 hr) around larvae located in the viscera. A pre-granulomatous reaction was characterized by gradative concentration of amebocytes around larvae, evolving two well-organized granulomas. In this work we confirmed the simultaneous occurrence of oral and percutaneous infections. Perilarval reaction, when very well developed, defined typical granulomatous structure, including epithelioid cell transformation. The infection also caused a systemic mobilization of amebocytes and provoked amebocyte-endothelium interactions.
Details
- Language :
- English
- ISSN :
- 00740276 and 16788060
- Volume :
- 94
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Memorias do Instituto Oswaldo Cruz
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.74354df31c0c438fa091f917fe4e610f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/S0074-02761999000400022