Biomarkers in Patients with Hand-Arm Vibration Injury Entailing Raynaud’s Phenomenon and Cold Sensitivity, Compared to Referents

The clinical evaluation of patients with neurosensory injury is based on quantitative sensory testing. Such tests require the patient’s cooperation, which may sometimes hinder a correct diagnosis. Objective findings, e.g., with biomarkers, would therefore be valuable. We evaluated serum biomarkers of vascular and neural injury in 92 patients with vibration injuries and in 64 referents. Thrombomodulin (TM), a biomarker for endothelial damage, was elevated in HAVS patients with Raynaud’s phenomenon (RP) compared to those without, as it also was in comparison to the referents. In the patients without RP, those with increased cold sensitivity showed somewhat higher—but not significantly different—values of TM (p = 0.4) than those without increased cold sensitivity, indicating an endothelial dysfunction or injury.