Back to Search Start Over

Ventricular arrhythmia events in heart failure patients with cardiac resynchronization therapy with or without a defibrillator for primary prevention

Authors :
Toshihiro Nakamura
Koji Fukuzawa
Kunihiko Kiuchi
Mitsuru Takami
Yusuke Sonoda
Hiroyuki Takahara
Kazutaka Nakasone
Kyoko Yamamoto
Yuya Suzuki
Ken‐ichi Tani
Hidehiro Iwai
Yusuke Nakanishi
Mitsuhiko Shoda
Atsushi Murakami
Shogo Yonehara
Ken‐ichi Hirata
Source :
Journal of Arrhythmia, Vol 38, Iss 6, Pp 1056-1062 (2022)
Publication Year :
2022
Publisher :
Wiley, 2022.

Abstract

Abstract Background It is uncertain whether cardiac resynchronization therapy with a defibrillator (CRT‐D) provides better survival benefits than a CRT‐pacemaker (CRT‐P) in heart failure patients with a reduced ejection fraction (≦35%, HFrEF) treated with contemporary HF therapy. Methods We retrospectively analyzed the ventricular arrhythmia (VAs; sustained ventricular tachycardia/fibrillation) events in HFrEF patients who underwent CRT without a prior history of VAs or aborted sudden cardiac death before the CRT implantation. Between January/2010 and December/2020, a CRT device was implanted in 79 HFrEF patients (mean age: 69 ± 12 years, male: 57, ischemic cardiomyopathy: 16). CRT‐D and CRT‐P devices were implanted in 50 and 29 patients, respectively, at each physician's discretion. CRT‐Ds were indicated in younger patients than were CRT‐Ps (66 ± 12 vs. 73 ± 12 years, p = 0.03), but the gender distribution did not differ (female, 24% [12 of 50] vs. 35% [10 of 29], p = 0.44). The VA events during a median follow‐up of 3.5‐years (interquartile range [IQR]:1.6–5.5) and their predictors were analyzed. Results VA events occurred in 9 patients with CRT‐Ds (18%) and one with a CRT‐P (3%, p = 0.08). The VA event rate was significantly lower in patients without a prior non‐sustained ventricular tachycardia (NSVT: ≥3 beats; rate, ≥120 bpm; lasting

Details

Language :
English
ISSN :
18832148 and 18804276
Volume :
38
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Journal of Arrhythmia
Publication Type :
Academic Journal
Accession number :
edsdoj.72f08f805554cb7b295f2e05152b1fe
Document Type :
article
Full Text :
https://doi.org/10.1002/joa3.12795