Clinical Characteristics and Influencing Factors of Bronchial Asthma Combined with Obstructive Sleep Apnea-hypopnea Syndrome in Children

Background Bronchial asthma (BA) and obstructive sleep apnea-hypopnea syndrome (OSAHS) are two major chronic diseases affecting the health of children. OSAHS may aggravate BA, adding to the difficulties in BA control, and BA can lead to the occurrence or progression of OSAHS through various mechanisms, such a relationship between them has attracted increasing attention. Objective To explore the clinical features and influencing factors of children with BA complicated with OSAHS. Methods One hundred and nine children with BA who were admitted to Children's Asthma Center, Gansu Provincial Maternity and Child Health Care Hospital from September 2021 to August 2022 were selected, including 49 with OSAHS (BA with OSAHS group) and 60 without (simple BA group). The general clinical data, pulmonary function test results, and serum levels of inflammatory cytokines, 25-hydroxyvitamin D 〔25 (OH) D〕 and C-reactive protein (CRP) were collected. The clinical features were analyzed, and factors associated with OSAHS in BA were analyzed by multivariate Logistic regression. Results Multivariate Logistic regression analysis showed that obesity〔OR=4.803, 95%CI (1.011, 2.822) 〕, enlarged neck circumference〔OR=1.318, 95%CI (1.003, 1.732) 〕 and gastroesophageal reflux disease (GERD) 〔OR=7.756, 95%CI (1.398, 43.045) 〕 were independent risk factors for OSAHS in BA children (P