Insulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liver.

Authors :: Isabel Roncero
Elvira Alvarez
Carlos Acosta
Carmen Sanz
Pedro Barrio
Veronica Hurtado-Carneiro
Deborah Burks
Enrique Blázquez
Source :: PLoS ONE, Vol 8, Iss 4, p e58797 (2013)
Publication Year :: 2013
Publisher :: Public Library of Science (PLoS), 2013.
Abstract: Insulin receptor substrate (IRS) proteins play important roles in hepatic nutrient homeostasis. Since glucokinase (GK) and glucokinase regulatory protein (GKRP) function as key glucose sensors, we have investigated the expression of GK and GKRP in liver of Irs-2 deficient mice and Irs2(-/-) mice where Irs2 was reintroduced specifically into pancreatic β-cells [RIP-Irs-2/IRS-2(-/-)]. We observed that liver GK activity was significantly lower (p

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