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Different cutoffs of hypertension, risk of incident diabetes and progression of insulin resistance: A prospective cohort study
- Source :
- Journal of the Formosan Medical Association, Vol 121, Iss 1, Pp 193-201 (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Background/Purpose: Hypertension is a risk factor of incident diabetes. In 2017, the ACC/AHA updated the definition of hypertension to above 130/80 mmHg, while the 2018 ESC/ESH guideline and the JNC7 criteria remained the cutoff of 140/90 mmHg. This study was aimed to investigate how different cutoffs of hypertension affect the association of hypertension to incident diabetes and the progression of insulin resistance. Methods: A total of 1177 subjects without diabetes at baseline were followed for 4.5 years. Diabetes was diagnosed by the results of oral glucose tolerance tests and hemoglobin A1c, or if anti-diabetic agents were used. Results: Hypertension by both criteria was associated with incident diabetes. Change of HOMA2-IR every 5 years (ΔHOMA2-IR/5 yr) was higher in subjects with hypertension than those without (adjusted p = 0.044). Subjects with treated hypertension had the highest risk of diabetes (HR 2.98, p
- Subjects :
- Cutoffs
Diabetes mellitus
Hypertension
Insulin resistance
Medicine (General)
R5-920
Subjects
Details
- Language :
- English
- ISSN :
- 09296646
- Volume :
- 121
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of the Formosan Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.71dfd1874dd4b1cb2fc0a7305ee21ff
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jfma.2021.02.022