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Selenium and the Methionine Sulfoxide Reductase System
- Source :
- Molecules, Vol 14, Iss 7, Pp 2337-2344 (2009)
- Publication Year :
- 2009
- Publisher :
- MDPI AG, 2009.
-
Abstract
- Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R- and the S- forms of MetO, respectively. The effects of a selenium deficient (SD) diet, which was administrated to wild type (WT) and MsrA knockout mice (MsrA-/-), on the expression and function of Msr-related proteins are examined and discussed. Additionally, new data about the levels of selenium in brain, liver, and kidneys of WT and MsrA-/- mice are presented and discussed.
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 14
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.71c9714f761446ba37f4ff12ca9ea7f
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/molecules14072337