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Modeling within-host effects of drugs on Plasmodium falciparum transmission and prospects for malaria elimination.
- Source :
- PLoS Computational Biology, Vol 10, Iss 1, p e1003434 (2014)
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Achieving a theoretical foundation for malaria elimination will require a detailed understanding of the quantitative relationships between patient treatment-seeking behavior, treatment coverage, and the effects of curative therapies that also block Plasmodium parasite transmission to mosquito vectors. Here, we report a mechanistic, within-host mathematical model that uses pharmacokinetic (PK) and pharmacodynamic (PD) data to simulate the effects of artemisinin-based combination therapies (ACTs) on Plasmodium falciparum transmission. To contextualize this model, we created a set of global maps of the fold reductions that would be necessary to reduce the malaria R C (i.e. its basic reproductive number under control) to below 1 and thus interrupt transmission. This modeling was applied to low-transmission settings, defined as having a R 0
- Subjects :
- Biology (General)
QH301-705.5
Subjects
Details
- Language :
- English
- ISSN :
- 1553734X and 15537358
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- PLoS Computational Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7167b31602f640889399b84c73b754c1
- Document Type :
- article
- Full Text :
- https://doi.org/10.1371/journal.pcbi.1003434