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Bone Sarcomas: From Biology to Targeted Therapies

Authors :
Nathalie Gaspar
Angela Di Giannatale
Birgit Geoerger
Françoise Redini
Nadège Corradini
Natacha Enz-Werle
Franck Tirode
Perrine Marec-Berard
Jean-Claude Gentet
Valérie Laurence
Sophie Piperno-Neumann
Odile Oberlin
Laurence Brugieres
Source :
Sarcoma, Vol 2012 (2012)
Publication Year :
2012
Publisher :
Hindawi Limited, 2012.

Abstract

Primary malignant bone tumours, osteosarcomas, and Ewing sarcomas are rare diseases which occur mainly in adolescents and young adults. With the current therapies, some patients remain very difficult to treat, such as tumour with poor histological response to preoperative CT (or large initial tumour volume for Ewing sarcomas not operated), patients with multiple metastases at or those who relapsed. In order to develop new therapies against these rare tumours, we need to unveil the key driving factors and molecular abnormalities behind the malignant characteristics and to broaden our understanding of the phenomena sustaining the metastatic phenotype and treatment resistance in these tumours. In this paper, starting with the biology of these tumours, we will discuss potential therapeutic targets aimed at increasing local tumour control, limiting metastatic spread, and finally improving patient survival.

Details

Language :
English
ISSN :
1357714X and 13691643
Volume :
2012
Database :
Directory of Open Access Journals
Journal :
Sarcoma
Publication Type :
Academic Journal
Accession number :
edsdoj.70eddb5c7b954b7a91c8b6bb68b5355b
Document Type :
article
Full Text :
https://doi.org/10.1155/2012/301975