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Schizophrenia and Hospital Admissions for Cardiovascular Events in a Large Population: The APNA Study

Authors :
Sara Guillen-Aguinaga
Antonio Brugos-Larumbe
Laura Guillen-Aguinaga
Felipe Ortuño
Francisco Guillen-Grima
Luis Forga
Ines Aguinaga-Ontoso
Source :
Journal of Cardiovascular Development and Disease, Vol 9, Iss 1, p 25 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

(1) Background: Patients with schizophrenia have higher mortality, with cardiovascular diseases being the first cause of mortality. This study aims to estimate the excess risk of hospital admission for cardiovascular events in schizophrenic patients, adjusting for comorbidity and risk factors. (2) Methods: The APNA study is a dynamic prospective cohort of all residents in Navarra, Spain. A total of 505,889 people over 18 years old were followed for five years. The endpoint was hospital admissions for a cardiovascular event. Direct Acyclic Graphs (DAG) and Cox regression were used. (3) Results: Schizophrenic patients had a Hazard Ratio (HR) of 1.414 (95% CI 1.031–1.938) of hospital admission for a cardiovascular event after adjusting for age, sex, hypertension, type 2 diabetes, dyslipidemia, smoking, low income, obesity, antecedents of cardiovascular disease, and smoking. In non-adherent to antipsychotic treatment schizophrenia patients, the HR was 2.232 (95% CI 1.267–3.933). (4) Conclusions: Patients with schizophrenia have a higher risk of hospital admission for cardiovascular events than persons with the same risk factors without schizophrenia. Primary care nursing interventions should monitor these patients and reduce cardiovascular risk factors.

Details

Language :
English
ISSN :
23083425
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Cardiovascular Development and Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.70b956ebd324aef9178fda698b2bc32
Document Type :
article
Full Text :
https://doi.org/10.3390/jcdd9010025