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Linear stability for a free boundary problem modeling the growth of tumor cord with time delay

Authors :
Haihua Zhou
Yaxin Liu
Zejia Wang
Huijuan Song
Source :
Mathematical Biosciences and Engineering, Vol 21, Iss 2, Pp 2344-2365 (2024)
Publication Year :
2024
Publisher :
AIMS Press, 2024.

Abstract

This paper was concerned with a free boundary problem modeling the growth of tumor cord with a time delay in cell proliferation, in which the cell location was incorporated, the domain was bounded in $ \mathbb{R}^2 $, and its boundary included two disjoint closed curves, one fixed and the other moving and a priori unknown. A parameter $ \mu $ represents the aggressiveness of the tumor. We proved that there exists a unique radially symmetric stationary solution for sufficiently small time delay, and this stationary solution is linearly stable under the nonradially symmetric perturbations for any $ \mu > 0 $. Moreover, adding the time delay in the model leads to a larger stationary tumor. If the tumor aggressiveness parameter is bigger, the time delay has a greater effect on the size of the stationary tumor, but it has no effect on the stability of the stationary solution.

Details

Language :
English
ISSN :
15510018
Volume :
21
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Mathematical Biosciences and Engineering
Publication Type :
Academic Journal
Accession number :
edsdoj.70996accd19f4f239e5bf8761d80a007
Document Type :
article
Full Text :
https://doi.org/10.3934/mbe.2024103?viewType=HTML