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Association between mechanical power and intensive care unit mortality in Korean patients under pressure-controlled ventilation

Authors :
Jae Kyeom Sim
Sang-Min Lee
Hyung Koo Kang
Kyung Chan Kim
Young Sam Kim
Yun Seong Kim
Won-Yeon Lee
Sunghoon Park
So Young Park
Ju-Hee Park
Yun Su Sim
Kwangha Lee
Yeon Joo Lee
Jin Hwa Lee
Heung Bum Lee
Chae-Man Lim
Won-Il Choi
Ji Young Hong
Won Jun Song
Gee Young Suh
Source :
Acute and Critical Care, Vol 39, Iss 1, Pp 91-99 (2024)
Publication Year :
2024
Publisher :
Korean Society of Critical Care Medicine, 2024.

Abstract

Background Mechanical power (MP) has been reported to be associated with clinical outcomes. Because the original MP equation is derived from paralyzed patients under volume-controlled ventilation, its application in practice could be limited in patients receiving pressure-controlled ventilation (PCV). Recently, a simplified equation for patients under PCV was developed. We investigated the association between MP and intensive care unit (ICU) mortality. Methods We conducted a retrospective analysis of Korean data from the Fourth International Study of Mechanical Ventilation. We extracted data of patients under PCV on day 1 and calculated MP using the following simplified equation: MPPCV = 0.098 ∙ respiratory rate ∙ tidal volume ∙ (ΔPinsp + positive end-expiratory pressure), where ΔPinsp is the change in airway pressure during inspiration. Patients were divided into survivors and non-survivors and then compared. Multivariable logistic regression was performed to determine association between MPPCV and ICU mortality. The interaction of MPPCV and use of neuromuscular blocking agent (NMBA) was also analyzed. Results A total of 125 patients was eligible for final analysis, of whom 38 died in the ICU. MPPCV was higher in non-survivors (17.6 vs. 26.3 J/min, P

Details

Language :
English
ISSN :
25866052 and 25866060
Volume :
39
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Acute and Critical Care
Publication Type :
Academic Journal
Accession number :
edsdoj.703f6c48f64583b02dd6b1681f2f8b
Document Type :
article
Full Text :
https://doi.org/10.4266/acc.2023.00871