Aging‐Related Decline of Glutathione Peroxidase 3 and Risk of Cardiovascular Events in Patients With Atrial Fibrillation

Background Experimental studies demonstrated that glutathione peroxidase 3 (GPx3), an antioxidant enzyme that catabolizes hydrogen peroxide, protects against thrombosis. Little is known about its role in cardiovascular disease. Methods and Results A prospective cohort study was conducted in 909 atrial fibrillation patients. Serum activities of GPx3, superoxide dismutase (SOD), and catalase were measured at baseline to assess the risk of cardiovascular events during a mean follow‐up of 43.4 months (3291 person‐years). Serum Nox2 and urinary excretion of 11‐deydro‐thromboxane B2 were also measured. During follow‐up 160 cardiovascular events occurred (4.9%/year). Significantly lower values of GPx3 (P