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Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to human and pangolin ACE2; although neither spike binds bat ACE2.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 12
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6fc3e78a8f74f72b0f0a1e0880a8bb4
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-021-21006-9