Recent development of electrochemical immunosensor for the diagnosis of dengue virus NSI protein: A review

Dengue virus is an important prevalent mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae (Flavivirus), which is transmitted by infected Aedes female mosquitoes and causes dengue fever. The challenge to control the transmission of these diseases and prompt sight of this virus is an international health problem at present. As a result of the scientific significance of its recognition, recently, the use of biosensors to sense and measure the disease with quick detection is one of the best methods, which is comparatively simple and practical, with high sensibility, accuracy, and selectivity rather than the traditional techniques such as immunology and molecular-based approaches. The electrochemical biosensor-based recognition method from biomolecules using transducers is a simple method, with the possibility of commercialization, inexpensiveness, simplicity, and convenience. Hence, several types of biosensing methods using different biosensors with transducers such as voltammetric, potentiometric, amperometric, and impedimetric are used for the detection of dengue NS1 protein. In this study, we aimed to find out the best biosensing method for the detection and diagnosis of dengue virus. We expect that dengue NS1-based electrochemical diagnostic techniques will open the horizons for growth in the coming times, with thrilling new opportunities for the advancement of commercial design of electrochemical biosensors.