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Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Notch receptors can exert different roles in cancer. In this manuscript, the authors reveal that Notch1 activation and EMT promote tumor initiation and cancer cell heterogeneity in squamous cell carcinoma, while the repression of Notch3 by ZEB1 limits Notch1-induced differentiation, permitting Notch1-mediated EMT.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6f8691ad6d324ab0a967f60181be89c5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-017-01500-9