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Metastatic Insulinoma in a Patient with Type 2 Diabetes Mellitus: Case Report and Review of the Literature

Authors :
Noormuhammad Oosman Abbasakoor
Marie Louise Healy
Donal O'Shea
Donal Maguire
Cian Muldoon
Kieran Sheahan
Dermot O'Toole
Source :
International Journal of Endocrinology, Vol 2011 (2011)
Publication Year :
2011
Publisher :
Hindawi Limited, 2011.

Abstract

Pancreatic neuroendocrine tumors (NETs) are extremely rare, and although insulinomas are the commonest, less than 10% of insulinomas are malignant. Most patients with insulinomas present with neuroglycopenic symptoms and weight gain attributable to insulin excess. Here, we report a case where a 67-year-old lady with a background history of type 2 diabetes mellitus and breakthrough hyperinsulinism who presented with coma. The biochemical profile revealed features typical of insulinoma, and CT and endosonography confirmed a pancreatic tumor with large volume right-sided liver metastases (biopsy confirming a neuroendocrine tumor). The patient underwent successful one-step RO surgical resection, distal pancreatectomy, splenectomy, and right hepatectomy, and 9 months postoperatively, she remains free of recurrent disease. She remains a diabetic.

Details

Language :
English
ISSN :
16878337 and 16878345
Volume :
2011
Database :
Directory of Open Access Journals
Journal :
International Journal of Endocrinology
Publication Type :
Academic Journal
Accession number :
edsdoj.6efce231850e4aebb8c2a2e08d302259
Document Type :
article
Full Text :
https://doi.org/10.1155/2011/124078