P8.3 RELATIONSHIP BETWEEN PULSE WAVE VELOCITY AND BIOPSY PROVEN RENAL MICROVASCULAR LESIONS

Aortic stiffness is associated to chronic kidney disease. Although it is well established that patients with chronic kidney disease have classical and non classical risk factors correlated to a high pulse wave velocity, there is no data on the deleterious effect of high pulse wave velocity on intra renal microvasculature. The aim of this study was to explore the relationship between arterial stiffness, assessed by cfPWV and renal microvascular lesions assessed by renal biopsy. In 25 patients who went through a renal biopsy we analysed renal vascular lesions, and obtained cfPWV using a Complior device. cfPWV and age were positively correlated to the severity of vascular lesions. These results support the hypoyhesis that an elevated pulsatility in target organ microcirculation such as kidneys leads to vessel damage and contributes to worsen glomerular filtration rate.