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Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors

Authors :
Cho Yeow Koh
Norrapat Shih
Christina Y. C. Yip
Aaron Wei Liang Li
Weiming Chen
Fathiah S. Amran
Esther Jia En Leong
Janaki Krishnamoorthy Iyer
Grace Croft
Muhammad Ibrahim Bin Mazlan
Yen-Lin Chee
Eng-Soo Yap
Dougald M. Monroe
Maureane Hoffman
Richard C. Becker
Dominique P. V. de Kleijn
Vaishali Verma
Amita Gupta
Vijay K. Chaudhary
A. Mark Richards
R. Manjunatha Kini
Mark Y. Chan
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Bleeding complications limits the use of effective antithrombotics therapeutics. Here, the authors developed next-generation direct thrombin inhibitors with low bleeding risks as safe peri-percutaneous coronary intervention anticoagulants when used in combination with antiplatelets.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6e99b695d4c66a9002c62027f15b1
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-27275-8