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Whole-genome mutational burden analysis of three pluripotency induction methods
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- It is feared that reprogramming may introduce DNA mutations. Here Bhutani et al. take three different reprogramming methods and using comparative whole genome analyses do identify nucleotide variations that are different in reprogrammed cells from the original fibroblasts, but none convey oncogenic potential.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6e8a5319f7e748139e1e8df30b2b96e0
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms10536