Rituximab for primary cutaneous large B-cell non-Hodgkin's lymphoma of the scalp

A 46-year-old man with a primary cutaneous large B-cell non-Hodgkin's lymphomas is reported. His mother died of gastric lymphoma and his sib brother is 20 years in a remission of T-cell lymphoma. He noticed the appearance of localized baldness and rash of the scalp 16 years before a hematological diagnosis was made. Diagnostic procedures performed in 2006 dem­onstrated progressive disease with crusted skin nodules (7x7.2cm) which exuded serous fluid. Histopathologcal and immuno­histochemical results suggested the diagnosis of a primary cutaneous large B-cell non-Hodgkin's lymphoma. The patient was treated with rituximab and chemotherapy (protocol R-CHOP) and achieved a complete remission. A rather protracted indolent phase of disease, the familial history of lymphoma, and an excellent response to immunochemotherapy contributed to an unusual presentation of this patient's disease.