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Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease

Authors :
Tuulia Hyötyläinen
Livnat Jerby
Elina M. Petäjä
Ismo Mattila
Sirkku Jäntti
Petri Auvinen
Amalia Gastaldelli
Hannele Yki-Järvinen
Eytan Ruppin
Matej Orešič
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a risk factor for other types of liver diseases. Here, the authors integrate transcriptomic and metabolomic data from patients with NAFLD with a genome-scale metabolic model to paint a comprehensive picture of liver function in NAFLD.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6e1fc59352494a63bee5cc567082d455
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms9994