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Fatty infiltration in the musculoskeletal system: pathological mechanisms and clinical implications

Authors :
Yihua Zhu
Yue Hu
Yalan Pan
Muzhe Li
Yuanyuan Niu
Tianchi Zhang
Haitao Sun
Shijie Zhou
Mengmin Liu
Yili Zhang
Chengjie Wu
Yong Ma
Yang Guo
Lining Wang
Source :
Frontiers in Endocrinology, Vol 15 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

Fatty infiltration denotes the anomalous accrual of adipocytes in non-adipose tissue, thereby generating toxic substances with the capacity to impede the ordinary physiological functions of various organs. With aging, the musculoskeletal system undergoes pronounced degenerative alterations, prompting heightened scrutiny regarding the contributory role of fatty infiltration in its pathophysiology. Several studies have demonstrated that fatty infiltration affects the normal metabolism of the musculoskeletal system, leading to substantial tissue damage. Nevertheless, a definitive and universally accepted generalization concerning the comprehensive effects of fatty infiltration on the musculoskeletal system remains elusive. As a result, this review summarizes the characteristics of different types of adipose tissue, the pathological mechanisms associated with fatty infiltration in bone, muscle, and the entirety of the musculoskeletal system, examines relevant clinical diseases, and explores potential therapeutic modalities. This review is intended to give researchers a better understanding of fatty infiltration and to contribute new ideas to the prevention and treatment of clinical musculoskeletal diseases.

Details

Language :
English
ISSN :
16642392
Volume :
15
Database :
Directory of Open Access Journals
Journal :
Frontiers in Endocrinology
Publication Type :
Academic Journal
Accession number :
edsdoj.6e1461eefcdb4efea1b803179f2152b6
Document Type :
article
Full Text :
https://doi.org/10.3389/fendo.2024.1406046