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Mechanisms and targets of Fcγ-receptor mediated immunity to malaria sporozoites

Authors :
Gaoqian Feng
Bruce D. Wines
Liriye Kurtovic
Jo-Anne Chan
Philippe Boeuf
Vanessa Mollard
Anton Cozijnsen
Damien R. Drew
Rob J. Center
Daniel L. Marshall
Sandra Chishimba
Geoffrey I. McFadden
Arlene E. Dent
Kiprotich Chelimo
Michelle J. Boyle
James W. Kazura
P. Mark Hogarth
James G. Beeson
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Antibodies plays critical roles in the adaptive immune response to infectious agents including malaria. Here the authors defined antibody interactions with -Fcγ-receptors expressed on immune cells with sporozoites of Plasmodium falciparum, and identified specific target epitopes of antibodies.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6df085e64a2441099441e81ae6947fa5
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-21998-4