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Pseudogenes in Cardiovascular Disease
- Source :
- Frontiers in Molecular Biosciences, Vol 7 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Cardiovascular disease is the main disease that affects human life span. In recent years, the disease has been increasingly addressed at the molecular levels, for example, pseudogenes are now known to be involved in the pathogenesis and development of cardiovascular diseases. Pseudogenes are non-coding homologs of protein-coding genes and were once called “junk gene.” Since they are highly homologous to their functional parental genes, it is somewhat difficult to distinguish them. With the development of sequencing technology and bioinformatics, pseudogenes have become readily identifiable. Recent studies indicate that pseudogenes are closely related to cardiovascular diseases. This review provides an overview of pseudogenes and their roles in the pathogenesis of cardiovascular diseases. This new knowledge adds to our understanding of cardiovascular disease at the molecular level and will help develop new biomarkers and therapeutic approaches designed to prevent and treat the disease.
Details
- Language :
- English
- ISSN :
- 2296889X
- Volume :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Molecular Biosciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6dd8cf71e04293a2646fc121e67629
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/fmolb.2020.622540