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Case report: Squamous cell carcinoma in situ of the cornea without involvement of the limbus and conjunctiva

Authors :
Ji Kyu Yun
Young Joon Ryu
Yongwoo Lee
Source :
Frontiers in Medicine, Vol 11 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

Isolated corneal squamous cell carcinoma without conjunctiva and limbus involvement is rare. We report a case of isolated squamous cell carcinoma in situ of the cornea. A 67-year-old male presented with visual disturbance in the left eye (visual acuity, 0.5), with a lesion isolated to the cornea. After an initial diagnosis of keratitis, he was lost to follow-up for 15 months. He subsequently returned for re-evaluation by a corneal specialist owing to progressive visual impairment in the left eye (visual acuity, 0.2). A left scrape biopsy and histopathological examination revealed squamous cell carcinoma in situ. No systemic evaluation findings of lymphadenopathy or metastasis were observed. Following removal of the residual mass from the cornea, conjunctival tissue samples, including the limbus, were collected for histopathological examination, with negative findings. No recurrence was observed at 15 months postoperatively. Isolated corneal squamous cell carcinoma in situ can be misdiagnosed as simple corneal opacity or keratitis during clinical examination. This condition should be considered in patients with unresponsive keratitis or corneal opacities.

Details

Language :
English
ISSN :
2296858X
Volume :
11
Database :
Directory of Open Access Journals
Journal :
Frontiers in Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.6dcc39fd97f64026ba0283ca3b1d48c7
Document Type :
article
Full Text :
https://doi.org/10.3389/fmed.2024.1418228