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Pistachio Extract Improves Neurocognitive Behaviors in Ovariectomized Mice
- Source :
- Research Journal of Pharmacognosy, Vol 6, Iss 4, Pp 45-51 (2019)
- Publication Year :
- 2019
- Publisher :
- Iranian Society of Pharmacognosy, 2019.
-
Abstract
- Background and objectives: Menopause is associated with depression as well as emotional and memory disorders. Based on the anti-inflammatory and antioxidant effects of pistachio, its effect on depression, cognitive function, anxiety and physical power in ovariectomized mice was investigated. Methods: In the current study, fifty female mice were used. They were aliquoted into five groups: control, ovariectomy (OVX), ovariectomy + DMSO, ovariectomy +10 mg/kg pistachioextract and Ovariectomy +100 mg/kg pistachio extract. In order to prepare the required extract, pistachio nuts were powdered (100 g) and macerated in 1 L of ethanol (80%) for 72 h. Pistachio extract was used orally once a day in ovariectomized mice for sixty days. Anxiety, depression, working memory and physical power were evaluated by the Elevated plus-maze (EPM) test, Forced swimming test (FST), Y maze and swimming exhaustion test, respectively. Results: The results showed that extract of pistachio (more potentially at the dose of 100 mg/kg) decreased anxiety-like behaviors and depression; besides, increase in working memory and physical power was observed in the ovariectomized mice. Conclusion: The findings of the current investigation suggest that pistachio extract could be used as a potential strategy for the attenuation of ovariectomy-related manifestation
- Subjects :
- Mice
ovariectomy
Pistacia vera
Pharmacy and materia medica
RS1-441
Subjects
Details
- Language :
- English
- ISSN :
- 23454458 and 23455977
- Volume :
- 6
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Research Journal of Pharmacognosy
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6d9f75527cf24d16b88897ca3d2974ab
- Document Type :
- article
- Full Text :
- https://doi.org/10.22127/rjp.2019.93515