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METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- METTL3 catalyzes mRNA m6A deposition. The authors identify an acetylation-mediated regulation of METTL3 subcellular localization and compartment-specific functions, a process that is fine-tuned by anti-inflammatory and pro-inflammatory signals, which ultimately determine breast cancer metastasis.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6d9c4809d19a4cadb353a7ca7474fad8
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-34209-5