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Contrast-Enhanced Mammography for Screening Women after Breast Conserving Surgery

Authors :
Jill Gluskin
Carolina Rossi Saccarelli
Daly Avendano
Maria Adele Marino
Almir G. V. Bitencourt
Melissa Pilewskie
Varadan Sevilimedu
Janice S. Sung
Katja Pinker
Maxine S. Jochelson
Source :
Cancers, Vol 12, Iss 12, p 3495 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

To investigate the value of contrast-enhanced mammography (CEM) compared to full-field digital mammography (FFDM) in screening breast cancer patients after breast-conserving surgery (BCS), this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved retrospective, single-institution study included 971 CEM exams in 541 asymptomatic patients treated with BCS who underwent screening CEM between January 2013 and November 2018. Histopathology, or at least a one-year follow-up, was used as the standard of reference. Twenty-one of 541 patients (3.9%) were diagnosed with ipsi- or contralateral breast cancer: six (28.6%) cancers were seen with low-energy images (equivalent to FFDM), an additional nine (42.9%) cancers were detected only on iodine (contrast-enhanced) images, and six interval cancers were identified within 365 days of a negative screening CEM. Of the 10 ipsilateral cancers detected on CEM, four were detected on low-energy images (40%). Of the five contralateral cancers detected on CEM, two were detected on low-energy images (40%). Overall, the cancer detection rate (CDR) for CEM was 15.4/1000 (15/971), and the positive predictive value (PPV3) of the biopsies performed was 42.9% (15/35). For findings seen on low-energy images, with or without contrast, the CDR was 6.2/1000 (6/971), and the PPV3 of the biopsies performed was 37.5% (6/16). In the post-BCS screening setting, CEM has a higher CDR than FFDM.

Details

Language :
English
ISSN :
20726694
Volume :
12
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
edsdoj.6d5d1b2d56cf41d6a46c3425e91720f4
Document Type :
article
Full Text :
https://doi.org/10.3390/cancers12123495