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Dietary omega 3 fatty acids and skeletal muscle metabolism: a review of clinical and preclinical studies

Authors :
Doussat Camille
Brioche Thomas
Casas François
Capel Fréderic
Feillet-Coudray Christine
Source :
Oilseeds and fats, crops and lipids, Vol 31, p 13 (2024)
Publication Year :
2024
Publisher :
EDP Sciences, 2024.

Abstract

Background: There is a myriad of metabolic roles of omega-3 fatty acids. More recently, studies have looked at omega-3 fatty acids effects on skeletal muscle. Objectives: The objective was to determine their effects in situations such as physical activity, obesity, sarcopenia and cachexia. Methods: Bibliographic searches focused on the PubMed database, looking in priority at systematic reviews, until November 2023. Twenty-seven papers were finally included. Results: Omega-3 fatty acids could increase protein anabolism, reduce protein catabolism in the context of exercise-related muscle damages, and could induce beneficial mitochondrial modifications. In obesity, omega-3 fatty acids participate in weight loss and its maintenance, and can help decrease insulin resistance. In sarcopenia atrophic conditions, omega 3 fatty acids allow muscle mass and function maintenance. In cancer cachexia, omega 3 fatty acids are more efficient at the pre-cachectic stage, as they can reduce protein catabolism and increase protein anabolism, but cannot reverse energy imbalance. Conclusions: Omega 3 fatty acids have multiple beneficial effects on skeletal muscle in physical activity, obesity, sarcopenia and cachexia. Yet, these effects are mediated by EPA and DHA, whose sources are solely of marine origins. As marine resources are overexploited, finding diverse sources of omega-3 fatty acids is crucial.

Details

Language :
English, French
ISSN :
22726977 and 22576614
Volume :
31
Database :
Directory of Open Access Journals
Journal :
Oilseeds and fats, crops and lipids
Publication Type :
Academic Journal
Accession number :
edsdoj.6d59a7b4b1a044d687f4b0e8d7387541
Document Type :
article
Full Text :
https://doi.org/10.1051/ocl/2024011