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The relationship between hypoxia and Alzheimer’s disease: an updated review

Authors :
Borui Tao
Wei Gong
Chengyuan Xu
Zhihui Ma
Jinyu Mei
Ming Chen
Source :
Frontiers in Aging Neuroscience, Vol 16 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases, and the most prevalent form of dementia. The main hallmarks for the diagnosis of AD are extracellular amyloid-beta (Aβ) plaque deposition and intracellular accumulation of highly hyperphosphorylated Tau protein as neurofibrillary tangles. The brain consumes more oxygen than any other organs, so it is more easily to be affected by hypoxia. Hypoxia has long been recognized as one of the possible causes of AD and other neurodegenerative diseases, but the exact mechanism has not been clarified. In this review, we will elucidate the connection between hypoxia-inducible factors-1α and AD, including its contribution to AD and its possible protective effects. Additionally, we will discuss the relationship between oxidative stress and AD as evidence show that oxidative stress acts on AD-related pathogenic factors such as mitochondrial dysfunction, Aβ deposition, inflammation, etc. Currently, there is no cure for AD. Given the close association between hypoxia, oxidative stress, and AD, along with current research on the protective effects of antioxidants against AD, we speculate that antioxidants could be a potential therapeutic approach for AD and worth further study.

Details

Language :
English
ISSN :
16634365
Volume :
16
Database :
Directory of Open Access Journals
Journal :
Frontiers in Aging Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.6d483902d2aa46f5a6703c370cfa1b2b
Document Type :
article
Full Text :
https://doi.org/10.3389/fnagi.2024.1402774