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Microbial-Catalyzed Biotransformation of Multifunctional Triterpenoids Derived from Phytonutrients
- Source :
- International Journal of Molecular Sciences, Vol 15, Iss 7, Pp 12027-12060 (2014)
- Publication Year :
- 2014
- Publisher :
- MDPI AG, 2014.
-
Abstract
- Microbial-catalyzed biotransformations have considerable potential for the generation of an enormous variety of structurally diversified organic compounds, especially natural products with complex structures like triterpenoids. They offer efficient and economical ways to produce semi-synthetic analogues and novel lead molecules. Microorganisms such as bacteria and fungi could catalyze chemo-, regio- and stereospecific hydroxylations of diverse triterpenoid substrates that are extremely difficult to produce by chemical routes. During recent years, considerable research has been performed on the microbial transformation of bioactive triterpenoids, in order to obtain biologically active molecules with diverse structures features. This article reviews the microbial modifications of tetranortriterpenoids, tetracyclic triterpenoids and pentacyclic triterpenoids.
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 15
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6d1ec1387db42058d0560d107688f36
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/ijms150712027