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STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity

Authors :
Hiroaki Ohishi
Seiru Shimada
Satoshi Uchino
Jieru Li
Yuko Sato
Manabu Shintani
Hitoshi Owada
Yasuyuki Ohkawa
Alexandros Pertsinidis
Takashi Yamamoto
Hiroshi Kimura
Hiroshi Ochiai
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Using the newly developed STREAMING-tag system, the authors find that clusters of RNA polymerase II and BRD4 are formed specifically in the transcriptionally active state near the Nanog gene in mouse embryonic stem cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6c98c1dca35547af9846761d5b135fd4
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-35286-2